healthSpring — Human Health: PK/PD, Microbiome, Biosignal, Drug Discovery
Pharmacokinetics, gut microbiome, biosignal processing — 795 checks across 7 clinical tracks, sovereign NLME replaces NONMEM
Domain
Pharmacokinetics, gut microbiome, biosignal processing, endocrinology, comparative medicine, drug discovery, NLME.
Repository: syntheticChemistry/healthSpring
The Science Story
healthSpring proves the ecoPrimals math infrastructure extends to human clinical applications. PK/PD models validated against canine data in neuralSpring transfer directly to human therapeutics via allometric scaling. The Anderson localization framework from wetSpring/hotSpring applies to gut microbiome colonization resistance. The “claim verification pipeline” — extracting quantifiable claims from clinical practice literature and validating against published registry data — is a novel methodology that generalizes to any medical reference.
Headline Results
- 795 checks (601 Rust + 194 Python cross-validation)
- 7 clinical tracks spanning the full breadth of human health computing
- Sovereign NLME (FOCE/SAEM) replaces proprietary NONMEM/Monolix
- Species-agnostic PK — same code handles canine AD, feline hyperthyroid, and human TRT
- Testosterone-gut axis (Exp037) bridges microbiome and endocrine via Anderson localization
Clinical Tracks
| Track | Domain | Key Models |
|---|---|---|
| 1 — PK/PD | Pharmacokinetics, dose-response | Hill, PBPK, population Monte Carlo, Michaelis-Menten |
| 2 — Microbiome | Gut ecology, colonization | Anderson gut lattice, C. diff, FMT, SCFA, serotonin |
| 3 — Biosignal | ECG, HRV, SpO2, EDA | Pan-Tompkins, arrhythmia classification, multi-channel fusion |
| 4 — Endocrinology | Testosterone PK, TRT | IM/pellet depot PK, testosterone-gut axis |
| 5 — NLME | Population PK estimation | Sovereign FOCE/SAEM, NCA, diagnostic plots |
| 6 — Comparative Medicine | Cross-species health | Species-agnostic PK, canine AD, feline hyperthyroid |
| 7 — Drug Discovery | Compound screening | MATRIX scoring, ADDRC HTS, iPSC validation |
Researchers Reproduced
| Researcher | Department | Domain |
|---|---|---|
| Andrea J. Gonzales | Pharmacology & Toxicology, MSU | Pharmacology, cytokine signaling |
| Charles Mok | Clinical Practice | Clinical endocrinology, TRT |
What the Constraint Revealed
The testosterone-gut axis (Exp037) bridges microbiome diversity and endocrine outcomes via Anderson localization, validating a cross-track hypothesis. ODE→WGSL codegen absorbed from wetSpring; uncertainty quantification absorbed from groundSpring — the springs feed each other.
Cross-Spring Connections
- ← neuralSpring: Hill/IC50, PK models, allometric scaling → human therapeutics
- ← wetSpring: diversity indices, Anderson lattice → gut colonization resistance, 16S pipeline
- ← groundSpring: uncertainty quantification for clinical measurements
- ← ludoSpring: Fitts/Hick for medical UI evaluation; engagement for patient compliance
- → biomeOS NUCLEUS: distributed health pipeline
baseCamp Papers
Paper 13 — see baseCamp Science for full list.