🧬 healthSpring Clinical PK-PD
Clinical pharmacokinetics and pharmacodynamics — drug interaction prediction and population modeling
Domain Profile
Clinical pharmacokinetics and pharmacodynamics validation covering PBPK compartmental modeling, dose-response curves, drug-drug interaction prediction, microbiome-mediated metabolism, and GPU-accelerated population pharmacokinetics.
Status: Domain profile complete. pseudoSpore emission pending validation of all 6 modules.
Module Status
| # | Module | Description | Status |
|---|---|---|---|
| 1 | PBPK Compartments | Multi-compartment ODE time-concentration curves | PENDING |
| 2 | PD Response | Hill equation dose-response surfaces | PENDING |
| 3 | Drug-Drug Interaction | CYP450 inhibition AUC fold-change prediction | PENDING |
| 4 | Microbiome Metabolism | Anderson localization colonization resistance | PENDING |
| 5 | Population PK | GPU Monte Carlo parameter distributions (N=10,000) | PENDING |
| 6 | Symbiont PK-PD | LTEE B5 colonization + therapeutic molecule production | PENDING |
0 of 6 modules passing. Awaiting spring validation runs.
Provenance
| Property | Value |
|---|---|
| Origin | ecoPrimals/springs/healthSpring |
| Version | 0.1.0 (domain profile) |
| Spring | healthSpring |
| Domain profile | domain_profile.toml shipped Wave 63 |
| Emission | Pending — awaiting module validation |
Validation Checks
From domain_profile.toml:
- Compartment mass balance (±0.1%)
- Hill curve monotonicity and EC50 inflection
- DDI AUC fold-change within 2-fold of published clinical data
- Microbiome diversity indices within ecological bounds
- Population PK 95% CI covers reference ranges
- Cross-tier parity (Rust vs Python golden values)
- GPU/CPU determinism (barraCuda bit-identical to cpu_fallback)
Translation Groups
| Group | Domain Concept | Computation |
|---|---|---|
| pbpk_compartments | Organ-level ADME | Multi-compartment RK4 ODE |
| pd_response | Dose-response curves | Hill function with EC50/Emax |
| drug_interaction | CYP450 inhibition/induction | Mechanistic static models |
| microbiome_metabolism | Gut xenobiotic metabolism | Anderson + Michaelis-Menten |
| population_pk | Inter-individual variability | GPU Monte Carlo sampling |
| symbiont_pkpd | Engineered symbiont therapy | Logistic + Hill coupled ODE |